Inside

Finding the Cures

Thomas R. Webb, PhD
Clues from nature inspire new anti-cancer drugs
St. Jude researchers have designed an efficient route to synthesizing a new type of anti-cancer drug, based on a chemical that bacteria use as a weapon against organisms they infect. The initial versions of the new drugs show significant activity against a range of cancer cells.
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Basic Science

The diverse research at St. Jude ranges from discovery-focused and hypothesis-testing laboratory studies to clinical trials of specific agents, regimens, or therapeutic interventions. We continually seek to translate knowledge acquired through basic research into novel approaches for clinical diagnosis and treatment. At the same time, our clinical and laboratory-based investigators use the challenges encountered in the clinic to focus the efforts of our research.

The Research Behind the Cures

Brenda Schulman, PhD, and her lab members

Study gives new insights into how cells accessorize their proteins

St. Jude investigators have gained new insight into how the cell’s vast array of proteins would instantly be reduced to a confusion of lethally malfunctioning molecules without a system for proteins to “accessorize” in order to regulate their function. Just as eyeglasses improve vision, a coat provides warmth or an umbrella wards off rain, cells use a set of proteins called ubiquitin-like proteins (UBLs) as accessories that adapt their function as needed in the cell.

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Scientific Report 2008

Scientific Report

Key research activities and publications by the investigators at St. Jude during 2007 are summarized in the Scientific Report 2008.